Prognostic Potential of Argyrophillic Nucleolar Organizer Regions (Agnors) in Oral Lesions: A Systematic Review

Early detection of oral squamous cell carcinoma (OSCC) and potentially malignant disorders (OPMD) is important for dental professionals to improve patient survival rates. More than half patients with cancer had advanced disease at the time diagnosis, indicating a lack early risk assessment biomarkers. The development new protein biomarkers will help in diagnosis treatment.The argyrophilic nucleolar organiser regions (AgNORs) staining technique simple cost-effective. These are replicatory markers that identify epithelial dysplasia. And it also plays very role differentiating benign, pre-malignant, lesions cavity. number AgNORs per has been considered an indicator cellular proliferative activity. Microscopically, NORs can be identified as well-defined black dots located throughout nucleus. agNOR quantity strictly proportional activity cell. AgNOR quantification helps determination degree dysplasia and, consequently, analysis its potential transformation. qualitative characteristics hyperplastic, premalignant, lesions. sliver useful studying structure nucleolus well variations valuable parameter tumour pathology.